Database : HANSEN Search on : ANTIGENOS HLA/IMUNOL [Subject descriptor] References found : 14 [refine] Displaying: 1 .. 14   in format [Detailed]

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Id: 19731 Author: Vilalva, Fernanda Castro Jobim Title: Determinação dos níveis séricos de MBL, dos anticorpos anti-PGL-I e dos alelos HLA de classe I e classe II em pacientes com hanseníase^ipt Determination of MBL and anti-PGL-I serum levels and HLA ClassI and II in patients with leprosy- Source: Bauru; s.n; 2010. 81 p. ilus, tab. Abstract: A hanseníase é uma doença infecto-contagiosa e endêmica, constitui grave problema de saúde pública por causar incapacidade física permanente. A doença caracteriza-se por apresentar um amplo espectro de manifestações clínicas que correspondem a distintos padrões de resposta imunológica diante do mesmo agente etiológico, o Mycobacterium leprae. Métodos sorológicos têm sido desenvolvidos com a finalidade de auxiliar no diagnóstico precoce e estados reacionais, no monitoramento da eficácia da quimioterapia e no estudo da epidemiologia da hanseníase. Este estudo teve como objetivos: avaliar os níveis séricos de Lectina Ligada a Manose (MBL) e dos anticorpos anti-PGL-I em poacientes com hanseníase, em atividades, atendidos no Instituto Lauro de Souza Lima, SP, com ou sem o tratamento de poliquimioterapia e nos estados reacionais tipo 1 e 2; correlacionar os resultados dos nívceis séricos de MBL, e dos anticorpos anti-PGL-I com o índice baciloscópico (IB); avaliar a freqüência dos alelos HLA de classe I e II (locus A, B, DR e DQ) neste grupo de pacientes. Para a avaliação do anticorpo anti-PGL-I e da MBL foram estudados 69 pacientes sendo 21 do gênero feminino e 48 do gênero masculino, com idade variando de 11 a 72 anos. Quanto a classificação clínica, 12 eram tuberculóides (HT), 23 vichovianos (HV) e 34 dimorfos [18 dimorfos-tuberculóides (HDT), 09 dimorfos-dimorfos (HDD) e 07 dimorfos-virchovianos (HDV)]. Entre os pacientes avaliados, 38 apresentaram reações, sendo 20 reação tipo 1 e 18 reação tipo 2. Quanto ao esquema de tratamento, 43 pacientes eram multibacilares (MB) e 26 paucibacilares (PB). Neste estudo foram avaliados marcadores labaratoriais séricos MBL e anti-PGL-I pelo método imunoenzimático (ELISA) e os antígenos de histocompatibilidade pelo método Reverse Line blot. Os resultados dos níveis de anti-PGL-I forma mais altos nos pacientes MB comparados aos PB e mostraram uma forte associação com a carga bacilar. Com relação à MBL, nossos achados sugerem... (AU)^ipt. Descriptors: Hanseníase/quimioter Anticorpos/imunol Antígenos HLA/imunol - Lectinas/imunol Location: BR191.1; WC335.504, V71a

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Id: 19709 Author: Wang, Li-Man; Kimura, Akinori; Satoh, Manatsu; Mineshita, Satoru. Title: HLA linked with leprosy in Southern China; HLA-linked resistance alleles to leprosy. Source: Int. J. Lepr;67(4):403-408, Dec., 1999. . Abstract: According to the World Health Organization recommended multidrug therapy (WHO/MDT), we have carried out this study to investigate the presence of HLA-linked susceptibility or resistance to leprosy in a southern Chinese population. Sixty-nine leprosy patients and 112 healthy controls participated in the study. HLA-DR2 subtypes, HLA-B and MHC Class I chain-related A (MICA) alleles were typed at the DNA level using the polymerase chain reaction-single strand conformation polymorphism method. The frequencies of HLA-DR2-DRB1 alleles did not show any significant differences between the patient and the control groups, suggesting that the disease susceptibility was not associated with the DR2 subtypes in this southern Chinese population. On the other hand, in the multibacillary (MB) patients significantly decreased allele frequencies of HLA-B46 (0.040 in MB patients vs 0.129 in controls) and MICA-A5 (0.200 vs 0.380) were observed compared with the healthy controls. The calculated relative risk (RR) for B46 was 0.28; for MICA-A5, 0.52. In addition, on haplotype analysis the frequency of the HLA-B46/MICA-A5 haplotype was significantly decreased in the MB patients compared to controls (0.060 vs 0.233, RR = 0.22, p < 0.01). These results suggest that an HLA-linked disease-resistant gene to MB leprosy in southern China is in strong linkage disequilibrium with the HLA-B46/MICA-A5 haplotype. In other words, the resistant gene may be located near the HLA-B/MICA region and not in the HLA-DR locus. (AU)^ien. Descriptors: Antígenos HLA/anal Antígenos HLA/imunol Hanseníase/genet Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1999/pdf/v67n4/v67n4a05.pdf / en Location: BR191.1

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Id: 19535 Author: Joko, Satoru; Numaga, Jiro; Kawashima, Hidetoshi; Namisato, Masako; Maeda, Hiroo. Title: Human leukocyte antigens in forms of leprosy among japanese patients. Source: Int. J. Lepr;68(1):49-56, Mar., 2000. tab. Abstract: Human leukocyte antigens (HLA) class II alleles were analyzed among Japanese leprosy patients to ascertain whether immunogenetic differences exist among the leprosy classification forms of Ridley and Jopling. Ninety-three unrelated Japanese leprosy patients (21 lepromatous, 24 borderline lepromatous, 17 mid-borderline, 26 borderline tuberculoid, 5 tuberculoid) and 114 healthy control subjects were investigated. The frequencies of HLA-DRB1*1501, -DRB5*0101, -DQA1*0102 and DQB1*0602 were significantly increased in all of the Japanese leprosy patients. The frequencies of HLA-DRB1*0405, -DQA1*03 and -DQB1*0401 were significantly decreased in the Japanese patients after correction of the p value. Conversely, there were no significantly different distributions of the HLA-DRB1, -DRB5, -DQA1, DQB1 alleles in the five subgroups of these patients. We conclude that HLA class II alleles were not associated with the form of leprosy. Other HLA, a non-HLA gene, and/or environmental factors may play a critical role in the different manifestations of leprosy.. (AU)^ien. Descriptors: Antígenos HLA/imunol Antígenos HLA/fisiol Hanseníase/imunol Hanseníase/fisiopatol Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/2000/pdf/v68n1/v68n1a07.pdf / en Location: BR191.1

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Id: 19259 Author: Latif, Amany M. Abdel; Essa, Eman A. Title: Study of HLA-DR expression on skin lesions of leprosy before and during multiple drug therapy. Source: Int. J. Lepr;70(2):104-110, Jun. 2002. ilus, tab. Abstract: Leprosy is a dynamic disease in which cell mediated immunity (CMI) plays an important role in host defense and control of the clinical spectrum. This study was carried out to detect immune activation in the granuloma of leprosy during multiple drug therapy (MDT) by studying the expression of human leukocytic antigen-DR (HLA-DR) in the granuloma before and during therapy. Skin punch biopsies were taken before and at least once 2-4 weeks after starting MDT in 20 newly diagnosed patients. Two biopsies, 2-4 weeks apart, were also taken from 10 new patients who did not yet receive any treatment, for comparison. Furthermore, biopsies were taken before and during corticosteroid therapy in five patients who developed reversal reaction during MDT. The biopsy specimens were studied for the expression of HLA-DR using the immunofluorescent staining which was found to be visibly increased in 17 out of 20 new cases (85%) within 2-4 weeks after starting MDT, while no change in the expression was noticed in those who did not receive any treatment (p < 0.001). This might reflect the increased production of interferon gamma (IFN gamma) specially from granuloma lymphocytes after being stimulated with the excessive release of mycobacterial antigen from killed bacilli during therapy. The five patients who developed reversal reaction during MDT had strong HLA-DR expression in the first biopsies which declined subsequently 2-6 weeks after starting prednisolone therapy. Our results suggest that CMI was activated in skin lesions of leprosy during MDT. Such activation was not only restricted to those who developed reversal reaction across the therapeutic course, which indicates that the difference between patients who developed such reaction and those who did not, was likely to be quantitative rather than qualitative, with a more exaggerated CMI response in the former. Furthermore, it seems that the beneficial effect of MDT is accompanied by important changes in the immune cell profile which have a great role in overcoming such infection.(AU)^ien. Descriptors: Antígenos HLA/imunol Hanseníase/genet Hanseníase/imunol Hanseníase/fisiopatol Hanseníase/terap Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/2002/pdf/v70n2/v70n2a02.pdf / en Location: BR191.1

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Id: 18372 Author: Silva, Sonia Maria Uso Ruiz; Carvalho, Claudia Peres Monteiro; Marcos, Elaine Valim Camarinha; Souza, Fabiana Covolo de; Ura, Somei; Almeida, Ricardo Augusto Monteiro de Barros. Title: Identificação dos alelos HLA de classe I e classe II em pacientes co-infectados com hanseniase e aids / Identification of HLA alleles clas I and class II in co-infected patients with leprosy and aids Source: Hansen. int;31(2):29-34, 2006. tab. Abstract: O complexo HLA tem sido amplamente estudado, na tentativa de elucidar os mecanismos que levam ao direcionamento da forma clínica na hanseníase. Foram observadas associações positivas dos alelos HLA-DR2 e HLA-DR3, com a forma tuberculóide (HT) e do alelo HLA-DQ1, com a forma virchoviana (HV). Em relação ao HIV os alelos de classe I, HLA-B35 e HLA-Cw4 parecem estar mais fortemente associados com a deterioração imunológica e com a aceleração da progressão para a aids e os alelos HLA-A1, HLA-B8, HLA-B27, HLA-Cw7 e os de classe II, HLA-DR3 e HLA-DQ2 com a progressão lenta da doença. Por não haver nenhum dado na literatura descrevendo a participação dos alelos HLA em indivíduos co-infectados com hanseníase e HIV, o presente estudo teve como objetivo avaliar a freqüência dos alelos HLA de Classe I e II (locus A, B, C, DR e DQ) em pacientes co-infectados, atendidos no Instituto Lauro de Souza Lima de Bauru. Foi possível observar que a presença de alelos descritos na literatura como associados com rápida progressão da aids parece não influenciar no espectro clínico da hanseníase. Embora a infecção pelo HIV cause profundos danos no sistema imune, não houve direcionamento para a forma virchoviana multibacilar como se poderia esperar. Estudos abrangendo maior casuística devem ser conduzidos para que os resultados sejam mais informativos uma vez que a co-infecção HIV/M.leprae é um evento importante em área endêmica para ambas as doenças. (AU). Descriptors: HANSENIASE/diag HANSENIASE/imunol HANSENIASE/fisiopatol ANTIGENOS HLA/quim ANTIGENOS HLA/uso diag ANTIGENOS HLA/imunol SINDROME DE IMUNODEFICIÊNCIA ADQUIRIDA/imunol Limits: ESTUDO COMPARATIVO Electronic Medium: Internet Location: BR191.1

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Id: 18030 Author: Carvalho, Claudia Peres Monteiro Title: Indentificação dos alelos HLA de classe I e classe II em pacientes co-infectados com hanseniase e AIDS Identification of alleles HLA of classroom I and classroom II in patients co-infectedes with leprosy and AIDS- Source: Bauru; s.n; 2007. 56 p. ilus, tab, graf. Abstract: A imunidade celular do hospedeiro e quem determina a evoluçao e o quadro clinico do paciente, tanto na hanseniase como na infecçao pelo virus da imunodeficiencia adquirida (HIV). O virus HIV, assim como o Micobacterium leprae (M. leprae) sao antigenos intracelulares que estimulam a resposta imune celular e o perfil Th1. Os linfocitos T (LT) reconhecem esses antigenos quando apresentados juntamente com as moleculas do complexo HLA na superficie da celula apresentadora de antigeno (APC), desencadeando a resposta imune especifica. Muitos estudos tem sido realizados na tentativa de associar o complexo HLA com as diversas patologias. Na hanseniase, o complexo HLA tem sido amplamente estudado, na tentativa de elucidar os mecanismos que levam ao direcionamento da forma clinica, uma vez que estes alelos atuam de forma direta na resposta imune atraves da apresentaçao do peptideo antigenico para celula T. Estudos realizados com os alelos HLA de classe I apresentaram resultados controversos enquanto que a maioria das pesquisas de classe II, os resultados sao mais concordantes revelando associaçoes positivas dos alelos HLA-DR2 e HLA-DR3, com a forma tuberculoide (HT) e do alelo HLA-DQ1, com a forma virchoviana (HV). No HIV os alelos HLA parecem estar mais fortemente associados a deterioraçao imunologica que com a manifestaçao clinica da doença. Varios estudos associam consistentemente os alelos de classe I, HLA-B35 e HLA-Cw4 com a aceleraçao da progressao para a aids enquanto os alelos HLA-A1, HLA-B8, HLA-B27, HLA-Cw7 e os de classe II, HLA-DR3 e HLA-DQ2 estao associados a progressao lenta...(AU). Descriptors: SINDROME DE IMUNODEFICIÊNCIA ADQUIRIDA/imunol SINDROME DE IMUNODEFICIÊNCIA ADQUIRIDA/microbiol SINDROME DE IMUNODEFICIÊNCIA ADQUIRIDA/fisiopatol HANSENIASE/imunol HANSENIASE/microbiol HANSENIASE/fisiopatol ANTIGENOS HLA/bios ANTIGENOS HLA/imunol ANTIGENOS HLA/fisiol - LINFOCINAS/imunol  LINFOCINAS/fisiol Limits: RELATO DE CASO ESTUDO COMPARATIVO HUMANO Location: BR191.1; WC335.500, C253i

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Id: 11002 Author: Meyer, Christian G; May, Jurgen; Stark, Klaus Title: Human leukocyte antigens in tuberculosis and leprosy ..- Source: s.l; s.n; apr. 1998. 7 p. ilus, tab. Descriptors: HANSENIASE ANTIGENOS HLA TUBERCULOSE Location: BR191.1; 07274/s

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Id: 10362 Author: Offung, Fredrik; Lundin, Knut E. A; Meloen, Robert; Mustafa, Abu Salim Title: Human T cell recognition of the Mycobacterium leprae LSR antigen: epitopes and HLA restriction ..- Source: s.l; s.n; 1999. 9 p. tab, graf. Descriptors: SEQUENCIA DE AMINOACIDOS ANTIGENOS DE BACTÉRIAS ANTIGENOS DE BACTÉRIAS PROTEINAS DE BACTÉRIAS PROTEINAS DE BACTÉRIAS EPITOPOS DE LINFOCITO T ANTIGENOS HLA TESTE DE HISTOCOMPATIBILIDADE IMUNIZAÇAO IMUNOFENOTIPAGEM HANSENIASE TRANSFORMAÇAO LINFOCITICA DADOS DE SEQUENCIA MOLECULAR MYCOBACTERIUM LEPRAE PEPTIDIOS PEPTIDIOS PEPTIDIOS PROTEINAS RECOMBINANTES DE FUSAO PROTEINAS RECOMBINANTES DE FUSAO LINFOCITOS T Limits: ANIMAL Location: BR191.1; 07494/s

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Id: 10228 Author: Rani, Rajni; Zaheer, S. A; Suresh, N. R; Walia, R; Parida, S. K; Mukherjee, A; Mukherjee, Rama; Talwar, G. P Title: Association of HLA antigens with differential responsiveness to mycobacterium w vaccine in multibacillary leprosy patients ..- Source: s.l; s.n; 1992. 6 p. tab. Descriptors: REAÇOES CRUZADAS ANTIGENOS HLA ANTIGENOS HLA ANTIGENOS HLA-A ANTIGENOS HLA-B ANTIGENOS HLA-DQ ANTIGENOS HLA-DR IMUNOFENOTIPAGEM ANTIGENO DE MITSUDA HANSENIASE HANSENIASE HANSENIASE MYCOBACTERIUM VACINAS DE PRODUTOS INATIVADOS Location: BR191.1; 06929/s

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Id: 10227 Author: Hill, Adrian V. S Title: HLA and infection ..- Source: s.l; s.n; 1992. 6 p. ilus, tab. Descriptors: SINDROME DE IMUNODEFICIENCIA ADQUIRIDA PORTADOR MAPEAMENTO CROMOSSOMICO ANTIGENOS HLA ANTIGENOS HLA ANTIGENOS HLA TESTE DE HISTOCOMPATIBILIDADE INFECÇAO INFECÇAO INFECÇAO HANSENIASE MALARIA POLIMORFISMO (GENÉTICA) SOROTIPAGEM Location: BR191.1; 06928/s

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Id: 9913 Author: Ottenhoff, Tom H. M Title: Immunology of leprosy: newm developments ..- Source: s.l; s.n; 1994. 9 p. ilus, graf. Descriptors: HANSENIASE HANSENIASE HANSENIASE VACINA BCG MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE LINFOCITOS T VACINAS SINTÉTICAS VIRULENCIA CITOCINAS ANTIGENOS HLA Location: BR191.1; 06878/s

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Id: 9427 Author: Chanarat, Prasit Title: Immunogenetic study in leprosy ..- Source: s.l; s.n; 1992. 7 p. tab, mapa. Descriptors: SUSCETIBILIDADE A DOENÇA SUSCETIBILIDADE A DOENÇA ANTIGENOS HLA ANTIGENOS HLA IMUNIDADE CELULAR HANSENIASE HANSENIASE HANSENIASE CAMUNDONGOS PREVALENCIA TAILANDIA SAUDE MUNDIAL Location: BR191.1; 06374/s

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Id: 9339 Author: Rani, Rajni; Zaheer, S. A; Mukherjee, Rama Title: Do human leukocyte antigens have a role to play in differential manifestation of multibacillary leprosy: a study on multibacillary leprosy patients from North India ..- Source: s.l; s.n; 1992. 4 p. tab. Descriptors: ANTIGENOS DE BACTÉRIAS SUSCETIBILIDADE A DOENÇA SUSCETIBILIDADE A DOENÇA ANTIGENOS HLA ANTIGENOS HLA ANTIGENO HLA-DR2 TOLERANCIA IMUNOLOGICA IMUNIDADE CELULAR INDIA HANSENIASE HANSENIASE HANSENIASE HANSENIASE DIMORFA HANSENIASE DIMORFA HANSENIASE DIMORFA HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE Limits: ESTUDO COMPARATIVO Location: BR191.1; 06463/s

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Id: 9337 Author: Hill, Adrian V. S Title: HLA and infection ..- Source: s.l; s.n; 1992. 5 p. ilus, tab. Descriptors: SINDROME DE IMUNODEFICIENCIA ADQUIRIDA PORTADOR MAPEAMENTO CROMOSSOMICO ANTIGENOS HLA ANTIGENOS HLA ANTIGENOS HLA TESTE DE HISTOCOMPATIBILIDADE INFECÇAO INFECÇAO INFECÇAO HANSENIASE MALARIA POLIMORFISMO (GENÉTICA) SOROTIPAGEM Location: BR191.1; 06465/s

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